Gene information
Official symbol CDKN1B
Official full name cyclin dependent kinase inhibitor 1B
Gene type protein-coding gene
Chromosome12p13.1
Alias symbolKIP1; P27KIP1
Resources
Entrez Gene 1027
HGNC HGNC:1785
Ensembl ENSG00000111276
Vega OTTHUMG00000149914
UCSC uc001rat.3
GO terms: 75 records
GO Description Category LogP Number of genes Detail
GO:0001101 response to acid chemical GO Biological Processes -10.2965313 26 More
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001890 placenta development GO Biological Processes -8.66149584 25 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0007219 Notch signaling pathway GO Biological Processes -2.15030944 11 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009743 response to carbohydrate GO Biological Processes -20.6536066 44 More
GO:0009746 response to hexose GO Biological Processes -16.2230361 35 More
GO:0009749 response to glucose GO Biological Processes -15.7538948 34 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0019210 kinase inhibitor activity GO Molecular Functions -2.42307363 9 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0019902 phosphatase binding GO Molecular Functions -2.86314983 18 More
GO:0019903 protein phosphatase binding GO Molecular Functions -3.28869574 16 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030308 negative regulation of cell growth GO Biological Processes -7.25826751 14 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0031072 heat shock protein binding GO Molecular Functions -1.83303292 11 More
GO:0031334 positive regulation of protein-containing complex assembly GO Biological Processes -8.84926570 16 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034284 response to monosaccharide GO Biological Processes -18.9205843 39 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043200 response to amino acid GO Biological Processes -9.16129691 23 More
GO:0043254 regulation of protein-containing complex assembly GO Biological Processes -7.63830100 21 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045732 positive regulation of protein catabolic process GO Biological Processes -6.83749864 15 More
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO Biological Processes -1.73908250 3 More
GO:0045787 positive regulation of cell cycle GO Biological Processes -4.54703082 15 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046686 response to cadmium ion GO Biological Processes -6.32553812 8 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048640 negative regulation of developmental growth GO Biological Processes -7.44784067 20 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048662 negative regulation of smooth muscle cell proliferation GO Biological Processes -21.7509412 30 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051495 positive regulation of cytoskeleton organization GO Biological Processes -3.67944181 20 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071248 cellular response to metal ion GO Biological Processes -4.26641514 21 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0090398 cellular senescence GO Biological Processes -3.46605627 5 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:1904031 positive regulation of cyclin-dependent protein kinase activity GO Biological Processes -1.64538233 3 More
GO:2000241 regulation of reproductive process GO Biological Processes -4.23306387 21 More
KEGG pathways: 11 records
KEGG Description Category LogP Number of genes Detail
hsa01522 Endocrine resistance KEGG Pathway -4.64858532 8 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04934 Cushing syndrome KEGG Pathway -3.26102406 8 More
hsa05165 Human papillomavirus infection KEGG Pathway -8.63301470 40 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05203 Viral carcinogenesis KEGG Pathway -1.94955729 7 More
hsa05220 Chronic myeloid leukemia KEGG Pathway -2.89550682 10 More
hsa05222 Small cell lung cancer KEGG Pathway -6.83164026 10 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
celecoxib PharmGKB 22336956 view
chembl35482 NCI 11031257 view
doxorubicin NCI 12576455 view
epoetin alfa NCI 15122318 view
epoetin beta NCI 11023508 view
lapatinib CIViC 25587029 view
methotrexate NCI 14512390 view
progesterone NCI 11590147 view
raltitrexed NCI 10047461 view
streptozocin NCI 11978652 view
tretinoin NCI 10837916 view
vincristine NCI 12576455 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NM_004064.5:c.-838C>A genomics myocardial infarction[diagnosis] myocardial infarction Gonzalez P et al. BMC Biol. 2004
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